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The sixth edition of Basic Immunology has been reviewedto include recent important advances in our knowledgeof the immune system. The original goals of this book,from the earliest edition, were to present current concepts in immunology cogently and also in sufficient detail that they would be understood by students of the discipline, as well as to emphasize clinical aspects,including disease pathogenesis and the development ofnovel therapies based on the basic science of immunology. These are the goals that we continue to strive for.With improving understanding of the normal immuneresponse, we believe it is possible to present the fundamental knowledge in a concise way. In addition, therehas been exciting progress in applying basic principles tounderstanding and treating human diseases, a topic that is of paramount interest for students of medicineand allied health sciences. Foremost among these recentadvances is the development of cancer immunotherapy,which dramatically illustrates how fundamental sciencecan be translated into clinical practice. More specifically, we have focused on the following objectives. First, we have presented the most important principles governing the function of the immune system by synthesizing key concepts from the vast amountof experimental data that have emerged in the field of immunology. Our judgment of what is most important is based largely on what is most clearly established byscientific investigation and is essential for understanding the major functions of the immune system. We have also prioritized content that is relevant to human health and disease. We have realized that in any concise discussion of complex phenomena, it is inevitablethat exceptions and caveats cannot be considered indetail, so these have largely been omitted. Second, we have focused on immune responses against infectious microbes, and most of our discussions of the immune system are in this context. Third, we have made liberal use of illustrations to highlight important principles,but we have reduced factual details that may be foundin more comprehensive textbooks. Fourth, we have d2c66b5586